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American Society of Microbiology ABMM Sample Questions (Q144-Q149):

NEW QUESTION # 144
A clinical microbiology laboratory is monitoring the emergence of resistance to colistin in Gram-negative bacteria. Resistance to colistin is often mediated by modifications of the bacterial lipopolysaccharide (LPS).
The genetic basis for acquired colistin resistance most commonly involves:

A. Acquisition of genes encoding efflux pumps that specifically target colistin.
B. Alterations in the outer membrane porin proteins, reducing colistin uptake.
C. Mutations in genes encoding enzymes that modify the lipid A component of LPS.
D. Production of enzymes that directly inactivate the colistin molecule.

Answer: C

NEW QUESTION # 145
A patient with a history of exposure to bats in a cave develops progressive neurological symptoms, including hydrophobia. The MOST likely viral etiology is:

A. Herpes simplex virus encephalitis
B. Rabies virus
C. West Nile virus
D. Japanese encephalitis virus

Answer: B

NEW QUESTION # 146
Which virus is recognized as the leading cause of sporadic, severe gastroenteritis in infants and young children globally, for which effective vaccines are now available?

A. Rotavirus
B. Norovirus
C. Astrovirus
D. Enteric Adenovirus (serotypes 40, 41)

Answer: A

NEW QUESTION # 147
A patient with a history of chronic lung disease develops a severe pneumonia. Bronchoalveolar lavage fluid reveals the presence of numerous cysts containing multiple nuclei, which stain positively with silver stains but poorly with Gram stain. The patient's CD4+ T-cell count is within the normal range. The MOST likely causative organism and the preferred treatment are:

A. Paragonimus westermani; praziquantel.
B. Pneumocystis jirovecii; trimethoprim-sulfamethoxazole.
C. Blastomyces dermatitidis; itraconazole.
D. Histoplasma capsulatum; amphotericin B followed by itraconazole.

Answer: B

NEW QUESTION # 148
A clinical microbiology laboratory is preparing to validate a new molecular assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA). To assess the positive predictive value (PPV) of the assay, they need to know:

A. The number of true negative results divided by the total number of true negative and false positive results.
B. The number of true positive results divided by the total number of true positive and false negative results.
C. The number of true positive results divided by the total number of positive test results.
D. The number of true negative results divided by the total number of negative test results.

Answer: C

NEW QUESTION # 149
......

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