This study is a post-hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial and the ASPREE-Fracture substudy. It aimed to determine whether higher levels of high-density lipoprotein cholesterol (HDL-C) are predictive of an increased fracture risk in healthy older adults. The study included 16,703 Australians aged 70 or older and 2,411 US participants aged 65 or older without evident cardiovascular disease, dementia, physical disability, and life-limiting chronic illness. The study found that each 1-SD increment in HDL-C level was associated with a 14% higher risk of fractures. These findings suggest that higher levels of HDL-C are associated with an increased fracture risk, independent of common risk factors for fractures.
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