Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest

This is a multicenter, randomized, controlled trial in the Netherlands, which assigned patients with an out-of-hospital cardiac arrest to receive extracorporeal CPR or conventional CPR (standard advanced cardiac life support). The primary outcome was survival with a favorable neurologic outcome, defined as a Cerebral Performance Category score of 1 or 2 at 30 days. The study found that at 30 days, 14 patients (20%) in the extracorporeal-CPR group were alive with a favorable neurologic outcome, as compared with 10 patients (16%) in the conventional-CPR group. The number of serious adverse events per patient was similar in the two groups. The study found that the extracorporeal CPR and conventional CPR had similar effects on survival with a favorable neurologic outcome in patients with refractory out-of-hospital cardiac arrest.

https://www.nejm.org/doi/full/10.1056/NEJMoa2204511?query=featured_home