In this study, 1000 patients with severe aortic stenosis and low surgical risk were randomly assigned to either undergo TAVR (transcatheter aortic-valve replacement) with a balloon-expandable valve or surgery. The primary outcome was a composite of death, stroke, or rehospitalization at 1 year. The study found that TAVR resulted in a lower rate of the composite primary outcome at 1 year compared to surgery (8.5% vs. 15.1%), as well as lower rates of stroke, death or stroke, new-onset atrial fibrillation, and shorter index hospitalization than surgery. There were no significant differences in major complications between the two groups.
https://www.nejm.org/doi/10.1056/NEJMoa1814052
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